Abstract
This article reveals the achievements in specific prevention techniques during the most common epidemics. Furthermore, it emphasizes the importance of prevention during the emerging new epidemics and pandemics. This article also demonstrates the effectiveness of immunoprophylaxis during wars and vaccines during the COVID-19 pandemic. The study’s relevance is due to modern epidemiological challenges related to the unsatisfactory state of immunoprophylaxis, the COVID-19 pandemic, the Russian-Ukrainian war, its epidemic consequences, and the sanitary and epidemiological well-being of the country. The aim is to carry out a holistic reproduction of medical scientists’activities that pursue specific means of prevention against infectious diseases in Ukraine in the second half of the XIX - XX centuries and its significance in modern epidemiological challenges. In this paper, we analyzed the contribution of the Kyiv Medical Societies to the development of specific prevention means during the spread of epidemics in the XIX-XX centuries. In particular, we focused on the activities of the Society of Kyiv Physicians and the Society for the Control of Infectious Diseases. Medical scientists of these societies have initiated the opening of the Bacteriological Institute in Kyiv as an essential research center for developing antibacterial agents in overcoming epidemics in Ukraine. To get acquainted with the means of specific prevention of infectious diseases, Ukrainian scientists adopted experience from their colleagues abroad and further improved it at home. This study discovered that domestic diphtheria serum, in its preventive and curative properties, was more effective than similar foreign sera. Furthermore, the effectiveness of immunoprophylaxis against such infectious diseases as diphtheria, cholera, scarlet fever, tetanus, and gas gangrene was also analyzed. In the paper, we also underline the epidemiological challenges of the 21st century. That includes the COVID-19 pandemic and the risks of infectious diseases such as cholera, tetanus, and gas gangrene during the Russian-Ukrainian war. We analyze the means of specific prevention against these infectious diseases and the effectiveness of vaccines since the COVID-19 pandemic. In particular, we emphasize the importance of vaccination as the most effective means of specific prevention against infectious diseases. The study found a significant contribution of Kyiv Medical Societies to the development of specific prevention techniques during the spread of epidemics. A prominent place in the scientific substantiation of antibacterial agents in overcoming epidemics belonged to the Kyiv Bacteriological Institute. The scientific research of the institute’s scientists aimed to develop and improve the technology of preparation of specific tools for the prevention and treatment of infectious diseases. Voluntary associations of doctors in the form of societies are still a theoretical and practical foundation for further development of preventive technologies, considering the old and the emerging new epidemics and pandemics. Current epidemiological challenges relate to the COVID-19 pandemic and the emergence of epidemic consequences of the large-scale Russian-Ukrainian war
Keywords
specific prophylaxis; serum; vaccine; Society of Kyiv Doctors; Society for the Control of Infectious Diseases; Bacteriological Institute; O. D. Pavlovsky; diphtheria; cholera; gas gangrene; tetanus; COVID-19
References
[1] All about COVID-19 vaccines in Ukraine: CoronaVac / Sinovac. (n. d.). Retrieved from: https://moz.gov.ua/article/news/use-pro-vakcini-vid-covid-19-v-ukraini-coronavacsinovac).
[2] All about vaccines from COVID-19 in Ukraine: Comirnaty from Pfizer-BioNTech. (n. d.). Retrieved from: https:// bit.ly/ Comirnaty_wild).
[3] AstraZeneca vaccine against COVID-19. (n. d.). Retrieved from https://uk.wikipedia.org/wiki/Вакцина_AstraZeneca_проти_COVID-19.
[4] Boychak, M. (2005). History of the Kyiv military hospital. Kyiv Hospital - the training base of the medical faculty of St. Vladimir and Kyiv Medical Institute. Kiyv: Pressa Ukrainyi.
[5] Bulavinova, K.O. (2021). Substantiation of the improved management system of immunization of the population. (Doctoral thesis. Ivano-Frankivsk, Ukraine).
[6] COVID statistics updated in Ukraine. (n. d.). Retrievedfrom: https://www.unian.ua/health/ country/koronavirus-v-ukrajini-statistika- zarazhen-covid-19-v-ukrajini-na-17-listopada-2021-novini-kiyeva-1612026.html.
[7] Diachenko, S.S. (1976). Before being founded in Kiev «Society for the fight against infectious diseases». Microbiological journal, 6(38),786-791.
[8] Dmytruk, V.I., & Zaslavska, H.O. (2017). Immunoprophylaxis of infectious diseases in children: reach and problems. Anti-vaccination as a factor of change in anti-vaccination immunization of the population. Actual infectology, 5(4),166-171. doi: 10.22141/2312-413x.5.4.2017.115728.
[9] Efficacy of different vaccines against coronavirus. (n. d.). Retrieved from https://bit.ly/vaccines_Delta.
[10] Epidemic situation with cholera in Ukraine. (n. d.). Retrievedfrom https://uozter.gov.ua/ua/pages/304.
[11] Illness for diphtheria in Ukraine in 2010-2019. (n. d.). Retrieved from: https://phc.org.ua/news/ zakhvoryuvanist-na-difteriyu-v-ukraini-u-2010-2019-rokakh.
[12] Kotsur, N.I. (2010). The contribution of scientists – members of the Society of Kyiv Doctors in overcoming epidemics (second half of the XIX - early XX centuries. Retrieved from https://inb.dnsgb.com.ua/2010-4/10_kotsur.pdf.
[13] Kotsur, N.I. (2011). Formation and development of hygienic science in Ukraine: the way through epochs and social upheavals (second half of the XIX - 20s of the XX century). Korsun-Shevchenkivskyi.
[14] Kuryshkova, D. Diphtheria in Ukraine: what to do and whether to panic. (2019). Retrievedfrom: https://www.bbc.com/ukrainian/features-50181595.
[15] Mavrutenkov, V.V. & Revenko, H.O. (2016). Vaccine prevention: achievements, problems and prospects. Medical perspectives, 3 (21), 56-60.
[16] Moderna. Everything you need to know about the vaccine used to vaccinate Ukrainians en masse. Retrievedfrom: https://www.bbc.com/ukrainian/features-57971820#:~:text=Moderna%20%D1%81%D1%85%D0%B2%D0%B0%D0%BB%D0%B5%D0%BD%D0%B0%20%D0%92%D1%81%D0%B5%D1%81%D0%B2%D1%96%D1%82%D0%BD%D1%8C%D0%BE%D1%8E%20%D0%BE%D1%80%D0%B3%D0%B0%D0%BD%D1%96%D0%B7%D0%B0%D1%86%D1%96%D1%94%D1%8E%20%D0%BE%D1%85%D0%BE%D1%80%D0%BE%D0%BD%D0%B8,AstraZeneca%20(Covishield%2C%20SKBio).
[17] On approval and implementation of medical and technological documents on standardization of medical care for anaerobic clostridial infection (gas gangrene). Order of the Ministry of Health of Ukraine No. 777 of July 27, 2016. Retrieved from https://ips.ligazakon.net/document/view/MOZ26292?an=1
[18] Pavlovskiy, A D. (1914). Purulent surgical infectious diseases in gunshot wounds and their etiology. Russian medicine, 6-50, 1083-1088; 1107-1111; 1136-1139; 1167-1168; 1177-1178.
[19] Pavlovskiy, A.D. (1896). On the preparation of antidiphtheria serum in Kyiv and how to use it. Proceedings of the Society of Kyiv Doctors with Protocol Applications. Kyiv, 27.
[20] Pavlovskiy, A.D. (1917). Gas Gangrene. Gas Phlegmon and Bronze Mug. Etiology and clinic. Kyiv, 120.
[21] Proceedings of the Society of Kyiv Doctors with appendices of protocols for 1895. (1985). Kyiv.
[22] Report on the activities of the Society for the fight against infectious diseases in Kiev for 1903. Eighth year. (1904). Kyiv.
[23] Report on the solemn annual meeting of the Society of Kyiv Doctors. (28 october 1895). Kyiv.
[24] Ruda, S.P. (2000). Essays on the history of microbiology in Ukraine (late XIX - early XX centuries.). Kyiv: IVTs Derzhkomstatu Ukrainy.
[25] The head of the Robert Koch Institute, declaring a significantly lower risk of falling ill with coronavirus in those who have been vaccinated. (n. d.). Retrieved from https://ua.interfax.com.ua/news/ general/ 777425.html.
[26] Tsiborovskyi, O.M. (2010). Establishment of the Society of Kyiv Physicians and its contribution to the development of medicine and health care (to the 170th anniversary of the Society of Kyiv Physicians. In History of establishment and formation of the Association of Kiev doctors (until 170 years of the Association of Kiev doctors) (pp. 87-92).
[27] Vasiutina, K. (2016). Vaccination in Ukraine: exit from the third crisis. Localdoctor, 10, 22-23.
[28] Zahorodnii, V.V. & Nekoval, V.T. (2010). Science and practical activity of the Association of Kiev doctors. In History of establishment and formation of the Association of Kiev doctors (until 170 years of the Association of Kiev doctors). (pp.9–21). Kiyv.